Overview

  • Product name
  • Description
    Rabbit polyclonal to STEAP4
  • Tested applications
    Suitable for: ELISA, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH from Human STEAP4.

  • Positive control
    • Human Liver and Skin tissues; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab113230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
IHC-P Use a concentration of 10 µg/ml.
ICC/IF 1/100 - 1/500.

Target

  • Function
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
  • Tissue specificity
    Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.
  • Sequence similarities
    Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • Cellular localization
    Cell membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • alpha-induced protein 9 antibody
    • Metalloreductase STEAP4 antibody
    • six transmembrane prostate protein 2 antibody
    • Six-transmembrane epithelial antigen of prostate 4 antibody
    • SixTransMembrane protein of prostate 2 antibody
    • STAMP 2 antibody
    • STAMP2 antibody
    • STEA4_HUMAN antibody
    • STEAP 4 antibody
    • STEAP family member 4 antibody
    • STEAP4 antibody
    • TIARP antibody
    • TNFAIP 9 antibody
    • TNFAIP9 antibody
    • Tumor necrosis factor antibody
    • tumor necrosis factor, alpha-induced protein 9 antibody
    • tumor necrosis-alpha-induced adipose-related protein antibody
    see all

Images

  • ab113230, at 10µg/ml, staining STEAP4 in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.
  • ab113230, at 10µg/ml, staining STEAP4 in Formalin-fixed, Paraffin-embedded Human Skin tissue by Immunohistochemistry.
  • ab113230 at 1/100 dilution staining STEAP4 in HeLa cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.

References

ab113230 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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