Recombinant
RabMAb

Anti-Stefin B antibody [EPR3930] (ab92463)

Overview

  • Product name
    Anti-Stefin B antibody [EPR3930]
    See all Stefin B primary antibodies
  • Description
    Rabbit monoclonal [EPR3930] to Stefin B
  • Tested applications
    Suitable for: WB, ICCmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues within Human Stefin B.

  • Positive control
    • Human bladder and U87-MG cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab92463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ICC
  • Application notes
    ICC: 1/250 - 1/500.
    WB: 1/1000 - 1/10,000. Predicted molecular weight: 11 kDa.

    Is unsuitable for Flow Cyt, IHC-P or IP.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
    • Involvement in disease
      Defects in CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) [MIM:254800]. EPM1 is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures. The onset, occurring between 6 and 13 years of age, is characterized by convulsions. Myoclonus begins 1 to 5 years later. The twitchings occur predominantly in the proximal muscles of the extremities and are bilaterally symmetrical, although asynchronous. At first small, they become late in the clinical course so violent that the victim is thrown to the floor. Mental deterioration and eventually dementia develop.
    • Sequence similarities
      Belongs to the cystatin family.
    • Cellular localization
      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • CHROW21 antibody
      • CPI B antibody
      • CPI-B antibody
      • CST 6 antibody
      • CST6 antibody
      • CSTB antibody
      • Cystatin B (stefin B) antibody
      • Cystatin B antibody
      • Cystatin-B antibody
      • CYTB antibody
      • CYTB_HUMAN antibody
      • EPM1 antibody
      • EPM1A antibody
      • Liver thiol proteinase inhibitor antibody
      • PME antibody
      • Stefin-B antibody
      • STF B antibody
      • STFB antibody
      • ULD antibody
      see all

    Images

    • All lanes : Anti-Stefin B antibody [EPR3930] (ab92463) at 1/1000 dilution

      Lane 1 : Human bladder lysate
      Lane 2 : U87-MG cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 11 kDa

    References

    ab92463 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab92463.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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