Overview

  • Product nameAnti-STEP / PTPN5 antibody [23E5]
    See all STEP / PTPN5 primary antibodies
  • Description
    Mouse monoclonal [23E5] to STEP / PTPN5
  • Specificityab77807 recognizes STEP61, STEP46, STEP38 and STEP20. Additional isoforms may be detected with higher concentrations of cell lysates and/or antibody.
  • Tested applicationsSuitable for: IHC-FoFr, WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:

    MCTPGCNEEGFGYLVSPR

    conjugated to KLH, corresponding to amino acids 57-74 of Rat STEP/ PTPN5

  • Positive control
    • Whole rat brain preparations.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab77807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent dilution.
WB 1/1000 - 1/10000. Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa).
IP Use at 8 µg/mg of lysate.

Target

  • FunctionMay regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ14427 antibody
    • Neural specific protein tyrosine phosphatase antibody
    • Neural-specific protein-tyrosine phosphatase antibody
    • Protein tyrosine phosphatase non receptor type 5 (striatum enriched) antibody
    • Protein tyrosine phosphatase non receptor type 5 antibody
    • Protein tyrosine phosphatase striatum enriched antibody
    • PTN5 antibody
    • PTN5_HUMAN antibody
    • PTP STEP antibody
    • PTPN 5 antibody
    • Ptpn5 antibody
    • PTPSTEP antibody
    • STEP antibody
    • Striatum-enriched protein-tyrosine phosphatase antibody
    • Tyrosine protein phosphatase non receptor type 5 antibody
    • Tyrosine-protein phosphatase non-receptor type 5 antibody
    see all

Anti-STEP / PTPN5 antibody [23E5] images

References for Anti-STEP / PTPN5 antibody [23E5] (ab77807)

This product has been referenced in:
  • Boulanger LM  et al. Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. J Neurosci 15:1532-44 (1995). Read more (PubMed: 7869116) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"