Anti-Sterol carrier protein 2 antibody (ab83858)

Overview

  • Product nameAnti-Sterol carrier protein 2 antibody
    See all Sterol carrier protein 2 primary antibodies
  • Description
    Rabbit polyclonal to Sterol carrier protein 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Pig, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptidecorresponding to a region within the internal amino acids 143-192 (NHKHSVNNPY SQFQDEYSLD EVMASKEVFD FLTILQCCPT SDGAAAAILA) of Human Sterol carrier protein 2 (NP_001007099).

  • Positive control
    • MCF7 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab83858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
  • Tissue specificityLiver, fibroblasts, and placenta.
  • Involvement in diseaseDefects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN) [MIM:613724]; also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine.
  • Sequence similaritiesIn the N-terminal section; belongs to the thiolase family.
    Contains 1 SCP2 domain.
  • Cellular localizationMitochondrion; Cytoplasm. Mitochondrion. Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues and Peroxisome. Interaction with PEX5 is essential for peroxisomal import.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686C12188 antibody
    • DKFZp686D11188 antibody
    • NLTP antibody
    • NLTP_HUMAN antibody
    • Non-specific lipid-transfer protein antibody
    • Nonspecific lipid transfer protein antibody
    • NSL TP antibody
    • NSL-TP antibody
    • OTTHUMP00000010488 antibody
    • OTTHUMP00000231766 antibody
    • OTTHUMP00000231767 antibody
    • OTTHUMP00000231768 antibody
    • OTTHUMP00000231769 antibody
    • OTTHUMP00000231770 antibody
    • OTTHUMP00000231772 antibody
    • OTTHUMP00000231773 antibody
    • OTTHUMP00000231774 antibody
    • OTTHUMP00000231776 antibody
    • OTTHUMP00000234662 antibody
    • Propanoyl CoA C acyltransferase antibody
    • Propanoyl-CoA C-acyltransferase antibody
    • SCP 2 antibody
    • SCP chi antibody
    • SCP X antibody
    • SCP-2 antibody
    • SCP-chi antibody
    • SCP-X antibody
    • SCP2 antibody
    • SCPchi antibody
    • SCPX antibody
    • Sterol carrier protein 2 antibody
    • Sterol carrier protein X antibody
    see all

Anti-Sterol carrier protein 2 antibody images

  • Anti-Sterol carrier protein 2 antibody (ab83858) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
    Additional bands at : >60 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Sterol carrier protein 2 antibody (ab83858)

ab83858 has not yet been referenced specifically in any publications.

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