The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 32 kDa.
Use at an assay dependent dilution.
FunctionThought to regulate cation conductance. May regulate ACCN1 and ACCN3 gating.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the band 7/mec-2 family.
Cellular localizationCell membrane. Cell membrane. Melanosome. Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.