Overview

  • Product name
  • Description
    Rabbit polyclonal to STOX1
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: SEFQPGSIRL EKHPKLPATQ PIPRIKSPNE MVGQKPLGEI TTVLGSHLIY KKRISNPFQG LSHRGSTISK GHKIQKTSDL KPSQTGPKEK, corresponding to amino acids 440-529 of Human STOX1.

  • Positive control
    • Human adrenal gland tissue, U-251 MG cells

Properties

Applications

Our Abpromise guarantee covers the use of ab122420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

Target

  • Involvement in disease
    Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]; also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. The pathological mechanism of PEE4 involves the loss of function of STOX1 in the placenta.
  • Cellular localization
    Nucleus; Nucleus > nucleolus and Cytoplasm. Nucleus. Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • C10orf24 antibody
    • chromosome 10 open reading frame 241 antibody
    • PEE4 antibody
    • storkhead box 1 antibody
    • Storkhead-box protein 1 antibody
    • STOX1 antibody
    • STOX1_HUMAN antibody
    • Winged-helix domain-containing protein antibody
    see all

Images

  • ab122420 at 1/50 dilution staining STOX1 in Paraffin-embedded Human adrenal gland tissue by Immunohistochemistry.
  • Immunofluorescent staining of Human cell line U-251 MG using ab122420 at a concentration of 4 µg/ml. ab122420 staining is shown in green.

References

ab122420 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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