Anti-STOX1 antibody - C-terminal (ab189436)

Overview

  • Product name
    Anti-STOX1 antibody - C-terminal
    See all STOX1 primary antibodies
  • Description
    Rabbit polyclonal to STOX1 - C-terminal
  • Specificity
    At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. ab189436 will recognize the longest isoform.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human STOX1 (C terminal). Raised against a 14 amino acid peptide near the C-terminal end.
    Database link: Q6ZVD7

  • Positive control
    • Human liver lysate. Human adrenal or skeletal muscle tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab189436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 111 kDa.

Target

  • Involvement in disease
    Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]; also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. The pathological mechanism of PEE4 involves the loss of function of STOX1 in the placenta.
  • Cellular localization
    Nucleus; Nucleus > nucleolus and Cytoplasm. Nucleus. Either found in the cytoplasm or in the nucleus. Nuclear expression of isoform A seems to be restricted to polyploid trophoblast cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • C10orf24 antibody
    • chromosome 10 open reading frame 241 antibody
    • PEE4 antibody
    • storkhead box 1 antibody
    • Storkhead-box protein 1 antibody
    • STOX1 antibody
    • STOX1_HUMAN antibody
    • Winged-helix domain-containing protein antibody
    see all

Images

  • All lanes : Anti-STOX1 antibody - C-terminal (ab189436) at 1 µg/ml

    Lane 1 : Human liver lysate
    Lane 2 : Human liver lysate plus blocking peptide


    Predicted band size : 111 kDa
  • Immunohistochemical analysis of formalin fixed, paraffin embedded human skeletal muscle labeling STOX1 with ab189436 at 5 μg/ml.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human adrenal tissue labeling STOX1 with ab189436 at 5 μg/ml.

References

ab189436 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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