Overview

  • Product name
  • Description
    Goat polyclonal to Stra6
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    QAFRKAALTSAKAN

    , corresponding to C terminal amino acids 653-665 of mouse (NP_033317.1) and rat (NP_001025095.1) Stra6

  • Positive control
    • Rat brain lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab77616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1/32000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 74 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex.
    • Tissue specificity
      Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
    • Involvement in disease
      Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9) [MIM:601186]; also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia.
      Note=Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • MCOPCB8 antibody
      • MCOPS9 antibody
      • PP14296 antibody
      • Stimulated by retinoic acid 6 homolog antibody
      • Stimulated by retinoic acid gene 6 protein homolog antibody
      • STRA6 antibody
      • STRA6_HUMAN antibody
      see all

    Images

    • Anti-Stra6 antibody (ab77616) at 0.3 µg/ml + rat brain lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 74 kDa
      Observed band size : 85 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    References

    ab77616 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab77616.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up