Anti-sTRAIL Receptor 2 antibody (Biotin) (ab116663)

Overview

  • Product name
    Anti-sTRAIL Receptor 2 antibody (Biotin)
    See all sTRAIL Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to sTRAIL Receptor 2 (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: WB, ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Highly pure (>98%) recombinant Human sTRAIL Receptor 2

Properties

  • Form
    Lyophilised:Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.20
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab116663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 48 kDa. The detection limit for recombinant Human TRAILReceptor 2 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
ELISA Use a concentration of 0.25 - 1 µg/ml. Use 100 µl/well of antibody solution. ab116663 allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human sTRAIL Receptor 2.
Sandwich ELISA Use a concentration of 0.25 - 1 µg/ml. Use 100 µl/well of antibody solution. ab116663, in conjunction with an sTRAIL Receptor 2 capture antibody allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human sTRAIL Receptor 2

Target

  • Function
    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
  • Tissue specificity
    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
  • Involvement in disease
    Squamous cell carcinoma of the head and neck
  • Sequence similarities
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apoptosis inducing protein TRICK2A 2B antibody
    • Apoptosis inducing protein TRICK2A/2B antibody
    • Apoptosis inducing receptor TRAIL R2 antibody
    • CD262 antibody
    • CD262 antigen antibody
    • Cytotoxic TRAIL receptor 2 antibody
    • Death domain containing receptor for TRAIL Apo 2L antibody
    • Death receptor 5 antibody
    • DR5 antibody
    • Fas like protein antibody
    • Killer antibody
    • Killer DR5 antibody
    • KILLER/DR5 antibody
    • p53 regulated DNA damage inducible cell death receptor killer antibody
    • p53 regulated DNA damage inducible cell death receptor(killer) antibody
    • TNF receptor superfamily member 10b antibody
    • TNF related apoptosis inducing ligand receptor 2 antibody
    • TNF-related apoptosis-inducing ligand receptor 2 antibody
    • TNFRSF10B antibody
    • TR10B_HUMAN antibody
    • Trail R2 antibody
    • TRAIL receptor 2 antibody
    • TRAIL-R2 antibody
    • TRAILR2 antibody
    • TRICK2 antibody
    • TRICK2A antibody
    • TRICK2B antibody
    • TRICKB antibody
    • Tumor necrosis factor receptor like protein ZTNFR9 antibody
    • Tumor necrosis factor receptor superfamily member 10B antibody
    • Tumor necrosis factor receptor superfamily, member 10b antibody
    • ZTNFR9 antibody
    see all

References

ab116663 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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