Overview

  • Product name
    Anti-Streptolysin antibody [6D11]
  • Description
    Mouse monoclonal [6D11] to Streptolysin
  • Specificity
    ab23501 is specific for oxidized streptolysin but cross reacts with untreated streptolysin
  • Tested applications
    Suitable for: ELISA, WB, ICC/IFmore details
  • Immunogen

    Cysteine chloride oxidized streptolysin.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    6D11
  • Myeloma
    x63-Ag8.653
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab23501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/400.
WB Use at an assay dependent concentration. PubMed: 21693578
ICC/IF Use at an assay dependent concentration. PubMed: 21693578

Target

  • Relevance
    Bacteria of the Streptococcus genera produce the exotoxin streptolysin. Anti-streptolysin antibody titers in patients are measured as a marker of inflammation. Streptolysin is also an important tool in cell biology due to its hemolytic activity and the ability to permeabilize plasma membranes. Sulfhydryl-activated toxin. Is able to lyse cholesterol containing membranes. Can be reversibly inactivated by oxidation. Cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes.
  • Cellular localization
    Secreted
  • Alternative names
    • Slo antibody
    • Streptolysin O antibody
    • Thiol activated cytolysin antibody

References

This product has been referenced in:
  • Horiuchi T  et al. Floating chip mounting system driven by repulsive force of permanent magnets for multiple on-site SPR immunoassay measurements. Sensors (Basel) 12:13964-84 (2012). Read more (PubMed: 23202030) »
  • Horiuchi T  et al. Passive fluidic chip composed of integrated vertical capillary tubes developed for on-site SPR immunoassay analysis targeting real samples. Sensors (Basel) 12:7095-108 (2012). Read more (PubMed: 22969339) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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