Overview

  • Product nameAnti-Streptolysin antibody [6D11]
  • Description
    Mouse monoclonal [6D11] to Streptolysin
  • Specificityab23501 is specific for oxidized streptolysin but cross reacts with untreated streptolysin
  • Tested applicationsSuitable for: ELISA, WB, ICC/IFmore details
  • Immunogen

    Cysteine chloride oxidized streptolysin.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number6D11
  • Myelomax63-Ag8.653
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab23501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/400.
WB Use at an assay dependent concentration. PubMed: 21693578
ICC/IF Use at an assay dependent concentration. PubMed: 21693578

Target

  • RelevanceBacteria of the Streptococcus genera produce the exotoxin streptolysin. Anti-streptolysin antibody titers in patients are measured as a marker of inflammation. Streptolysin is also an important tool in cell biology due to its hemolytic activity and the ability to permeabilize plasma membranes. Sulfhydryl-activated toxin. Is able to lyse cholesterol containing membranes. Can be reversibly inactivated by oxidation. Cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes.
  • Cellular localizationSecreted
  • Alternative names
    • Slo antibody
    • Streptolysin O antibody
    • Thiol activated cytolysin antibody

References for Anti-Streptolysin antibody [6D11] (ab23501)

This product has been referenced in:
  • Keyel PA  et al. Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane. J Cell Sci 124:2414-23 (2011). ICC/IF, WB . Read more (PubMed: 21693578) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"