Overview

  • Product name
    Anti-Streptolysin antibody [6D11]
  • Description
    Mouse monoclonal [6D11] to Streptolysin
  • Specificity
    ab23501 is specific for oxidized streptolysin but cross reacts with untreated streptolysin
  • Tested applications
    Suitable for: ELISA, WB, ICC/IFmore details
  • Immunogen

    Cysteine chloride oxidized streptolysin.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    6D11
  • Myeloma
    x63-Ag8.653
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab23501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/400.
WB Use at an assay dependent concentration. PubMed: 21693578
ICC/IF Use at an assay dependent concentration. PubMed: 21693578

Target

  • Relevance
    Bacteria of the Streptococcus genera produce the exotoxin streptolysin. Anti-streptolysin antibody titers in patients are measured as a marker of inflammation. Streptolysin is also an important tool in cell biology due to its hemolytic activity and the ability to permeabilize plasma membranes. Sulfhydryl-activated toxin. Is able to lyse cholesterol containing membranes. Can be reversibly inactivated by oxidation. Cholesterol is the receptor for the binding of these toxins to eukaryotic cell membranes.
  • Cellular localization
    Secreted
  • Alternative names
    • Slo antibody
    • Streptolysin O antibody
    • Thiol activated cytolysin antibody

References for Anti-Streptolysin antibody [6D11] (ab23501)

This product has been referenced in:
  • Keyel PA  et al. Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane. J Cell Sci 124:2414-23 (2011). ICC/IF, WB . Read more (PubMed: 21693578) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab23501.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up