Anti-Stromal interaction molecule 1 antibody (ab123595)


  • Product nameAnti-Stromal interaction molecule 1 antibody
    See all Stromal interaction molecule 1 primary antibodies
  • Description
    Rabbit polyclonal to Stromal interaction molecule 1
  • Tested applicationsSuitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Dog, Chimpanzee, Gorilla, Chinese Hamster, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 550-600 of Human Stromal interaction molecule 1 (NP_003147.2).

  • Positive control
    • HeLa whole cell lysate.



Our Abpromise guarantee covers the use of ab123595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionPlays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
    • Tissue specificityUbiquitously expressed in various human primary cells and tumor cell lines.
    • Involvement in diseaseDefects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
    • Sequence similaritiesContains 1 EF-hand domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • DomainThe microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
    • Post-translational
      Glycosylation is required for cell surface expression.
      Phosphorylated predominantly on Ser residues.
    • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
    • Information by UniProt
    • Database links
    • Alternative names
      • D11S4896E antibody
      • GOK antibody
      • OTTHUMP00000164512 antibody
      • OTTHUMP00000229140 antibody
      • OTTHUMP00000230742 antibody
      • SIM antibody
      • STIM 1 antibody
      • STIM1 antibody
      • Stim1 stromal interaction molecule 1 antibody
      • STIM1_HUMAN antibody
      • STIM1L antibody
      • Stromal interaction molecule 1 antibody
      see all

    Anti-Stromal interaction molecule 1 antibody images

    • Detection of Stromal interaction molecule 1 by Western Blot of Immunprecipitate.
      anti-Stromal interaction molecule 1 antibody (recognizing a downstream epitope) at 1µg/ml staining Stromal interaction molecule 1 in HeLa whole cell lysate immunoprecipitated using ab123595 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 3 minutes.

    References for Anti-Stromal interaction molecule 1 antibody (ab123595)

    ab123595 has not yet been referenced specifically in any publications.

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