Biological descriptionCompetitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.
Chemical nameStrychnidin-10-one hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
García-Colunga J & Miledi R Modulation of nicotinic acetylcholine receptors by strychnine. Proc Natl Acad Sci U S A96:4113-8 (1999).
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Halsey MJ et al. Systemically administered glycine protects against strychnine convulsions, but not the behavioural effects of high pressure, in mice. J Physiol408:431-41 (1989).
Read more (PubMed: 2778736) »
Young AB & Snyder SH Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A70:2832-6 (1973).
Read more (PubMed: 4200724) »