Overview

  • Product name
  • Description
    Rabbit polyclonal to Sts1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 117-649 of Human Sts1.

  • Positive control
    • Jurkat and THP-1 whole cell lysates; Human hepatoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab155307 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 73 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
  • Sequence similarities
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cbl interacting protein p70 antibody
    • Cbl interacting protein Sts 1 antibody
    • Cbl interacting protein Sts1 antibody
    • Cbl-interacting protein p70 antibody
    • KIAA1959 antibody
    • MGC15437 antibody
    • Nm23 phosphorylated unknown substrate antibody
    • p70 antibody
    • SH3 domain containing 70 kDa protein antibody
    • Sts 1 antibody
    • STS-1 antibody
    • STS1 antibody
    • Suppressor of T cell receptor signaling 1 antibody
    • Suppressor of T-cell receptor signaling 1 antibody
    • T-cell ubiquitin ligand 2 antibody
    • TULA-2 antibody
    • Tyrosine-protein phosphatase STS1/TULA2 antibody
    • Ubash3b antibody
    • Ubiquitin associated and SH3 domain containing B antibody
    • Ubiquitin-associated and SH3 domain-containing protein B antibody
    • UBS3B_HUMAN antibody
    see all

Images

  • All lanes : Anti-Sts1 antibody (ab155307) at 1/5000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : THP-1 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 73 kDa
  • Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue, labeling Sts1 with ab155307 at 1/500 dilution.

References

This product has been referenced in:
  • Ye DJ  et al. Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells. Biomol Ther (Seoul) 25:321-328 (2017). Read more (PubMed: 27956712) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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