Overview

  • Product name
  • Description
    Rabbit polyclonal to Sts1
  • Tested applications
    Suitable for: WB, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to the C-terminus of mouse Sts-1.

Properties

Applications

Our Abpromise guarantee covers the use of ab34781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 72 kDa.
ICC/IF Use at an assay dependent dilution.
ELISA 1/2000 - 1/10000.

Target

  • Function
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
  • Sequence similarities
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cbl interacting protein p70 antibody
    • Cbl interacting protein Sts 1 antibody
    • Cbl interacting protein Sts1 antibody
    • Cbl-interacting protein p70 antibody
    • KIAA1959 antibody
    • MGC15437 antibody
    • Nm23 phosphorylated unknown substrate antibody
    • p70 antibody
    • SH3 domain containing 70 kDa protein antibody
    • Sts 1 antibody
    • STS-1 antibody
    • STS1 antibody
    • Suppressor of T cell receptor signaling 1 antibody
    • Suppressor of T-cell receptor signaling 1 antibody
    • T-cell ubiquitin ligand 2 antibody
    • TULA-2 antibody
    • Tyrosine-protein phosphatase STS1/TULA2 antibody
    • Ubash3b antibody
    • Ubiquitin associated and SH3 domain containing B antibody
    • Ubiquitin-associated and SH3 domain-containing protein B antibody
    • UBS3B_HUMAN antibody
    see all

References

This product has been referenced in:
  • Hu H  et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med 213:399-414 (2016). WB ; Mouse . Read more (PubMed: 26903241) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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