The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use at 2-5 µg/mg of lysate.
Application notesIs unsuitable for WB.
FunctionE3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
Tissue specificityHighly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
PathwayProtein modification; protein ubiquitination.
Carboxy terminus of Hsp70 interacting protein antibody
Carboxy terminus of Hsp70-interacting protein antibody
Carboxy terminus of Hsp70p interacting protein antibody
CLL associated antigen KW 8 antibody
CLL-associated antigen KW-8 antibody
E3 ubiquitin protein ligase CHIP antibody
E3 ubiquitin-protein ligase CHIP antibody
Heat shock protein A binding protein 2 (c terminal) antibody
NY CO 7 antibody
Serologically defined colon cancer antigen 7 antibody
STIP1 homology and U Box containing protein 1 antibody
STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody
STIP1 homology and U box-containing protein 1 antibody
STUB 1 antibody
UBOX 1 antibody
Anti-STUB1 antibody images
Immunoprecipitation - STUB1 antibody (ab80601)
Detection of Human STUB1 by Immunoprecipitation. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Lane 1: ab80601 used for IP at 3 mcg/mg lysate. Lane 2: IP with a control IgG. An other antibody anti STUB1 was subsequently used for Western blot detection. Chemiluminescence with an exposure time of 30 seconds.
References for Anti-STUB1 antibody (ab80601)
has not yet been referenced specifically in any publications.
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