Overview

  • Product nameAnti-STX11 antibody
    See all STX11 primary antibodies
  • Description
    Mouse polyclonal to STX11
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    STX11 (NP_003755.2, 1 a.a. ~ 287 a.a) full-length human protein.

  • Positive control
    • Human spleen and STX11 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab69828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • FunctionSNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
  • Involvement in diseaseDefects in STX11 are the cause of hemophagocytic lymphohistiocytosis familial type 4 (FHL4) [MIM:603552]; also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T lymphocytes in lymph nodes, spleen, and other organs is also found.
  • Sequence similaritiesBelongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localizationMembrane. Golgi apparatus > trans-Golgi network membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FHL4 antibody
    • HLH4 antibody
    • HPLH4 antibody
    • Stx11 antibody
    • STX11_HUMAN antibody
    • Syntaxin 11 antibody
    • Syntaxin-11 antibody
    see all

Anti-STX11 antibody images

  • Anti-STX11 antibody (ab69828) at 1/500 dilution + human spleen lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 33 kDa
    Observed band size : 31 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-STX11 antibody (ab69828) at 1/500 dilution

    Lane 1 : STX11 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 33 kDa
    Observed band size : 33 kDa

References for Anti-STX11 antibody (ab69828)

This product has been referenced in:
  • Hellewell AL  et al. Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells. PLoS One 9:e98900 (2014). Human . Read more (PubMed: 24910990) »
  • Izbicka E  et al. Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women. Cancer Genomics Proteomics 9:27-35 (2012). WB ; Human . Read more (PubMed: 22210046) »

See all 2 Publications for this product

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