Anti-STXBP2 antibody (ab103976)


  • Product nameAnti-STXBP2 antibody
    See all STXBP2 primary antibodies
  • Description
    Rabbit polyclonal to STXBP2
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 310-524 of Human STXBP2 (AAH02869).

  • Positive control
    • A431 and HepG2 cell lines. H1299 and HeLa whole cell lysate.



Our Abpromise guarantee covers the use of ab103976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 66 kDa.
ICC/IF 1/200. Use with paraformaldehyde fixed cells.


  • FunctionInvolved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • Tissue specificityPlacenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • Involvement in diseaseDefects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • Sequence similaritiesBelongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt
  • Database links
  • Alternative names
    • FHL5 antibody
    • Hunc18b antibody
    • MUNC18 2 antibody
    • pp10122 antibody
    • Protein unc-18 homolog 2 antibody
    • Protein unc-18 homolog B antibody
    • STXB2_HUMAN antibody
    • Stxbp2 antibody
    • syntaxin binding protein 2 antibody
    • Syntaxin-binding protein 2 antibody
    • Unc-18B antibody
    • UNC18 2 antibody
    • Unc18-2 antibody
    • UNC18B antibody
    see all

Anti-STXBP2 antibody images

  • All lanes : Anti-STXBP2 antibody (ab103976) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 66 kDa
  • ab103976 (1/200) staining STXBP2 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (red). For further experimental details please refer to Abreview.

    See Abreview

References for Anti-STXBP2 antibody (ab103976)

ab103976 has not yet been referenced specifically in any publications.

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Unfortunately ab103976 has never been tested in Flow Cytometry assays. It doesn’t mean it won’t work in this application, but we don’t have data to support it.

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Specification HeLa
Fixative Paraformaldehyde
Permeabilization Yes - 0.5% Triton-X100 in PBS

Dr. Kirk Mcmanus

Verified customer

Submitted Apr 24 2012