Overview

  • Product nameAnti-STXBP2 antibody
    See all STXBP2 primary antibodies
  • Description
    Rabbit polyclonal to STXBP2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 439-469 of Human STXBP2 (UniProt ID: Q15833).

  • Positive control
    • 293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab123679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 66 kDa.

Target

  • FunctionInvolved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • Tissue specificityPlacenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • Involvement in diseaseDefects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • Sequence similaritiesBelongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt
  • Database links
  • Alternative names
    • FHL5 antibody
    • Hunc18b antibody
    • MUNC18 2 antibody
    • pp10122 antibody
    • Protein unc-18 homolog 2 antibody
    • Protein unc-18 homolog B antibody
    • STXB2_HUMAN antibody
    • Stxbp2 antibody
    • syntaxin binding protein 2 antibody
    • Syntaxin-binding protein 2 antibody
    • Unc-18B antibody
    • UNC18 2 antibody
    • Unc18-2 antibody
    • UNC18B antibody
    see all

Anti-STXBP2 antibody images

  • Anti-STXBP2 antibody (ab123679) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size : 66 kDa

References for Anti-STXBP2 antibody (ab123679)

ab123679 has not yet been referenced specifically in any publications.

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