Overview

  • Product name
    Suc-Leu-Leu-Val-Tyr-AMC
  • Description
    Fluorogenic substrate of calpains and 20S proteasome
  • Biological description
    Fluorogenic substrate of calpains and 20S proteasome. Calpain I and II hydrolyses Suc-Leu-Leu-Val-Tyr-AMC with Km values of 203 and 466 µM, respectively. Used to study the activity of calpains and proteosomal degradation.
  • Purity
    > 97%

Properties

    References for Suc-Leu-Leu-Val-Tyr-AMC (ab142120)

    This product has been referenced in:
    • Stein RL  et al. Kinetic characterization of the chymotryptic activity of the 20S proteasome. Biochemistry 35:3899-908 (1996). Read more (PubMed: 8672420) »
    • Wang KK  et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A 93:6687-92 (1996). Read more (PubMed: 8692879) »
    • Tsubuki S  et al. Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome. Biochem Biophys Res Commun 196:1195-201 (1993). Read more (PubMed: 8250877) »
    • Sasaki T  et al. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem 259:12489-94 (1984). Read more (PubMed: 6092335) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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