Overview

  • Product name
  • Description
    Rabbit polyclonal to SUCLA2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 138-386 of Human SUCLA2 (NP_003841)

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, Molt-4 and Raji cells

Properties

Applications

Our Abpromise guarantee covers the use of ab97868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.

Target

  • Function
    Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA.
  • Tissue specificity
    Widely expressed. Not expressed in liver and lung.
  • Pathway
    Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
  • Involvement in disease
    Mitochondrial DNA depletion syndrome 5
  • Sequence similarities
    Belongs to the succinate/malate CoA ligase beta subunit family.
    Contains 1 ATP-grasp domain.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • A BETA antibody
    • A SCS antibody
    • ATP specific succinyl CoA synthetase subunit beta antibody
    • ATP specific succinyl CoA synthetase, beta subunit antibody
    • ATP-specific succinyl-CoA synthetase subunit beta antibody
    • Mitochondrial succinyl CoA ligase [ADP forming] subunit beta antibody
    • MTDPS5 antibody
    • Renal carcinoma antigen NY-REN-39 antibody
    • Renal carcinoma antigen NYREN39 antibody
    • SCS betaA antibody
    • SCS-betaA antibody
    • SUCB1_HUMAN antibody
    • Succinate CoA ligase (ADP forming) antibody
    • Succinate CoA ligase [ADP forming] subunit beta, mitochondrial; succinyl CoA ligase [ADP forming] subunit beta, mitochondrial antibody
    • Succinate CoA ligase ADP forming beta subunit antibody
    • Succinate CoA ligase beta subunit antibody
    • Succinyl CoA ligase [ADP-forming] subunit beta, mitochondrial antibody
    • Succinyl CoA synthetase beta A chain antibody
    • Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial antibody
    • Succinyl-CoA synthetase beta-A chain antibody
    • SUCLA2 antibody
    see all

Images

  • All lanes : Anti-SUCLA2 antibody (ab97868) at 1/1000 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : Molt-4 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 50 kDa

References

This product has been referenced in:
  • Nogueira C  et al. A Novel SUCLA2 Mutation in a Portuguese Child Associated With "Mild" Methylmalonic Aciduria. J Child Neurol N/A:N/A (2014). Human . Read more (PubMed: 24659738) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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