Overview

  • Product name
  • Description
    Rabbit polyclonal to SUGT1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-295 of Human SUGT1 (Q9Y2Z0-2).

  • Positive control
    • 293T, A431, H1299, HeLaS3, HepG2, MOLT4 and Raji whole cell lysates; HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab151483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/300. Predicted molecular weight: 38 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
  • Sequence similarities
    Belongs to the SGT1 family.
    Contains 1 CS domain.
    Contains 1 SGS domain.
    Contains 3 TPR repeats.
  • Domain
    The CS domain mediates interaction with HSP90.
  • Post-translational
    modifications
    Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
  • Cellular localization
    Cytoplasm. Nucleus. Translocates to the nucleus upon heat shock, requiring S100A6.
  • Information by UniProt
  • Database links
  • Alternative names
    • Protein 40 6 3 antibody
    • Protein 40-6-3 antibody
    • Protein SGT1 homolog antibody
    • Putative 40 6 3 protein antibody
    • Sgt1 antibody
    • SGT1 suppressor of G2 allele of SKP1 antibody
    • SGT1_HUMAN antibody
    • SGT1B protein antibody
    • sugt1 antibody
    • Suppressor of G2 allele of SKP1 homolog antibody
    • Suppressor of G2 allele of SKP1 S. cerevisiae homolog of antibody
    see all

Images

  • Anti-SUGT1 antibody (ab151483) at 1/1000 dilution + HepG2 whole cell lysate
    at 30 µg

    Predicted band size: 38 kDa



    12% SDS PAGE
  • Immunofluorescent analysis of paraformaldehyde fixed HeLa cells labeling SUGT1 with ab151483 at 1/200. Lower image merged with DNA probe.

References

ab151483 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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