Overview

  • Product name
  • Description
    Mouse polyclonal to Sulfatase 1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Full length protein, corresponding to amino acids 1-871 of Human Sulfatase 1 (NP_055985).

  • Positive control
    • Sulfatase 1 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 101 kDa.

Target

  • Function
    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
  • Tissue specificity
    Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
  • Sequence similarities
    Belongs to the sulfatase family.
  • Post-translational
    modifications
    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Cellular localization
    Endoplasmic reticulum. Golgi apparatus > Golgi stack. Cell surface. Also localized on the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • DSulf antibody
    • Extracellular sulfatase Sulf 1 antibody
    • Extracellular sulfatase Sulf-1 antibody
    • Extracellular sulfatase Sulf1 antibody
    • HSULF 1 antibody
    • HSulf-1 antibody
    • Neu5 antibody
    • Sulf1 antibody
    • SULF1_HUMAN antibody
    • Sulfatase FP antibody
    • Sulfated antibody
    see all

Images

  • All lanes : Anti-Sulfatase 1 antibody (ab168616) at 1 µg/ml

    Lane 1 : Sulfatase 1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 101 kDa

References

ab168616 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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