Overview

  • Product name
    Sumatriptan succinate
  • Description
    5-HT1 receptor agonist
  • Biological description
    5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively). Also shows affinity for 5-HT1F receptor (EC50 = 247 nM). Reduces vascular inflammation associated with migraine.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Nelson DL  et al. Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan. Cephalalgia 30:1159-69 (2010). Read more (PubMed: 20855361) »
  • Razzaque Z  et al. Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br J Clin Pharmacol 47:75-82 (1999). Read more (PubMed: 10073743) »
  • Peroutka SJ & McCarthy BG Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol 163:133-6 (1989). Read more (PubMed: 2545459) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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