Overview

  • Product nameAnti-Sumo 2 antibody
    See all Sumo 2 primary antibodies
  • Description
    Rabbit polyclonal to Sumo 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Xenopus laevis
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region between N terminal amino acids 1-30 of Xenopus laevis Sumo 2 (Q7ZTK7).

  • Positive control
    • 293 cell lysates transiently transfected with Sumo 2

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99.91% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesThis antibody is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab112931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 11 kDa.

Target

  • FunctionUbiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
  • Tissue specificityBroadly expressed.
  • Sequence similaritiesBelongs to the ubiquitin family. SUMO subfamily.
    Contains 1 ubiquitin-like domain.
  • Post-translational
    modifications
    Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
    Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
  • Cellular localizationNucleus. Nuclear bodies.
  • Information by UniProt
  • Database links
    • Alternative names
      • HSMT 3 antibody
      • HSMT3 antibody
      • MGC117191 antibody
      • Sentrin 2 antibody
      • Sentrin-2 antibody
      • Sentrin2 antibody
      • Small ubiquitin like modifier 2 antibody
      • Small ubiquitin related modifier 2 antibody
      • Small ubiquitin-related modifier 2 antibody
      • SMT 3B antibody
      • SMT3 homolog 2 antibody
      • SMT3 suppressor of mif two 3 homolog 2 antibody
      • SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody
      • SMT3, yeast, homolog 2 antibody
      • Smt3A antibody
      • SMT3B antibody
      • SMT3H2 antibody
      • SUMO-2 antibody
      • SUMO-3 antibody
      • SUMO2 antibody
      • SUMO2_HUMAN antibody
      • Sumo3 antibody
      • Ubiquitin like protein SMT3B antibody
      • Ubiquitin-like protein SMT3A antibody
      see all

    Anti-Sumo 2 antibody images

    • All lanes : Anti-Sumo 2 antibody (ab112931) at 1/100 dilution

      Lane 1 : Nontransfected 293 cell lysates
      Lane 2 : 293 cell lysates transiently transfected with Sumo 2

      Lysates/proteins at 2 µg per lane.


      Predicted band size : 11 kDa

    References for Anti-Sumo 2 antibody (ab112931)

    ab112931 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"