Sunitinib malate (Sutent) (DMSO solution) (ab146615)

Overview

  • Product name
    Sunitinib malate (Sutent) (DMSO solution)
  • Description
    Potent, ATP-competitive receptor tyrosine kinase inhibitor
  • Biological description
    Potent, ATP-competitive receptor tyrosine kinase inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively). Antitumor in vivo. Orally active. Crosses the blood-brain barrier.

    Also available as a solid (ab141998).
  • Purity
    > 99%

Properties

  • Chemical name
    N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malate
  • Molecular weight
    532.57
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H27FN4O2.C4H6O5
  • CAS Number
    341031-54-7
  • PubChem identifier
    6456015
  • Storage instructions
    Store at -20°C long term. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in DMSO (100 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
  • Source

    Synthetic

References

ab146615 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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