Overview

  • Product name
    Anti-Superoxide Dismutase 3 antibody
    See all Superoxide Dismutase 3 primary antibodies
  • Description
    Rabbit polyclonal to Superoxide Dismutase 3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit
  • Immunogen

    Synthetic peptide derived from Superoxide Dismutase 3

  • Positive control
    • Rat and mouse Lung Tissue Extract; Human Superoxide Dismutase 3 Protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab83108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 35 kDa (predicted molecular weight: 26 kDa).

Target

  • Function
    Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
  • Tissue specificity
    Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
  • Sequence similarities
    Belongs to the Cu-Zn superoxide dismutase family.
  • Cellular localization
    Secreted > extracellular space. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC SOD antibody
    • EC-SOD antibody
    • Extracellular superoxide dismutase [Cu Zn] antibody
    • Extracellular superoxide dismutase [Cu-Zn] antibody
    • Extracellular superoxide dismutase antibody
    • Extracellular superoxide dismutase precursor antibody
    • MGC20077 antibody
    • SOD 3 antibody
    • SOD3 antibody
    • SODE_HUMAN antibody
    • Superoxide dismutase 3 extracellular antibody
    see all

Images

  • All lanes : Anti-Superoxide Dismutase 3 antibody (ab83108) at 1/1000 dilution

    Lane 1 : Rat lung tissue extract
    Lane 2 : Mouse lung tissue extract
    Lane 3 : Human Superoxide Dismutase 3 protein

    Developed using the ECL technique

    Predicted band size : 26 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 40 kDa (possible glycosylated form),60 kDa (possible dimer).

References

This product has been referenced in:
  • Ramiro-Diaz JM  et al. Mechanisms of NFATc3 activation by increased superoxide and reduced hydrogen peroxide in pulmonary arterial smooth muscle. Am J Physiol Cell Physiol 307:C928-38 (2014). Read more (PubMed: 25163518) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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