Rabbit monoclonal [EPR10860] to Superoxide Dismutase 3
WB, IHC-Pmore details Unsuitable for:
ICC/IF or IP
Human Does not react with:
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Superoxide Dismutase 3 aa 200 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: P08294
Human fetal lung and heart lysates; Human heart and kidney tissues.
This product is a recombinant rabbit monoclonal antibody.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Belongs to the Cu-Zn superoxide dismutase family.
Secreted > extracellular space. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
Bodega G et al. The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles. Oxid Med Cell Longev2017:7094781 (2017).
Read more (PubMed: 28642812) »
Kim CH Expression of extracellular superoxide dismutase protein in diabetes. Arch Plast Surg40:517-21 (2013).
Read more (PubMed: 24086803) »