Anti-Suppressor of Fused antibody (ab118596)

Overview

  • Product nameAnti-Suppressor of Fused antibody
    See all Suppressor of Fused primary antibodies
  • Description
    Goat polyclonal to Suppressor of Fused
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Cynomolgus Monkey
  • Immunogen

    Synthetic peptide:

    AELRPSGAPGPT-C

    , corresponding to amino acids 2-13 of Human Suppressor of Fused (NP_057253.2).

  • Positive control
    • Human prostate and tonsil tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab118596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • FunctionNegative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation.
  • Tissue specificityUbiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney.
  • Involvement in diseaseMedulloblastoma
  • Sequence similaritiesBelongs to the SUFU family.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • OTTHUMP00000020374 antibody
    • OTTHUMP00000020377 antibody
    • OTTHUMP00000020379 antibody
    • PRO1280 antibody
    • SU FU antibody
    • SU(F)U antibody
    • Su(fu) antibody
    • SUFU antibody
    • SUFU negative regulator of hedgehog signaling antibody
    • SUFU_HUMAN antibody
    • SUFUH antibody
    • SUFUXL antibody
    • Suppressor of fused homolog (Drosophila) antibody
    • Suppressor of fused homolog antibody
    see all

Anti-Suppressor of Fused antibody images

  • ab118596, at 7.5 µg/ml, staining Suppressor of Fused in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.
  • ab118596, at 7.5 µg/ml, staining Suppressor of Fused in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

References for Anti-Suppressor of Fused antibody (ab118596)

ab118596 has not yet been referenced specifically in any publications.

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