Anti-Suppressor of Ty 4 homolog 1 antibody (ab105426)


  • Product nameAnti-Suppressor of Ty 4 homolog 1 antibody
    See all Suppressor of Ty 4 homolog 1 primary antibodies
  • Description
    Rabbit polyclonal to Suppressor of Ty 4 homolog 1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 35-84 (NCDAYLQMKG NREMVYDCTS SSFDGIIAMM SPEDSWVSKW QRVSNFKPGV) of Human Suppressor of Ty 4 homolog 1 (NP_003159).

  • Positive control
    • 293T cell lysate



Our Abpromise guarantee covers the use of ab105426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 13 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionComponent of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the SPT4 family.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DRB sensitivity-inducing factor 14 kDa subunit antibody
    • DRB sensitivity-inducing factor small subunit antibody
    • DSIF p14 antibody
    • DSIF small subunit antibody
    • hSPT4 antibody
    • SPT4 antibody
    • SPT4H antibody
    • SPT4H_HUMAN antibody
    • SUPT4H `1 antibody
    • SUPT4H antibody
    • Supt4h1 antibody
    • Transcription elongation factor spt4 antibody
    see all

Anti-Suppressor of Ty 4 homolog 1 antibody images

  • Anti-Suppressor of Ty 4 homolog 1 antibody (ab105426) at 1 µg/ml + 293T cell lysate at 10 µg

    Predicted band size : 13 kDa

References for Anti-Suppressor of Ty 4 homolog 1 antibody (ab105426)

ab105426 has not yet been referenced specifically in any publications.

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