Overview

  • Product nameSuramin hexasodium salt
  • Description
    Non-selective P2 purinergic antagonist
  • Biological descriptionNon-selective P2 purinergic antagonist (pEC50 values are 4.5 (P2X2), 5.4 (P2X5), 4.3 (P2Y2), 4.0 (P2Y4) and 4.8 (P2Y11)). Displays diverse biological actions. Shows antitumor activity, inhibits binding of multiple growth factors and additionally inhibits glutamatergic synaptic transmission.
  • Purity> 99%

Properties

    References for Suramin hexasodium salt (ab120422)

    This product has been referenced in:
    • Taniguti AP  et al. Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-ß1 blocker. Muscle Nerve 43:82-7 (2011). Read more (PubMed: 21108244) »
    • Gever JR  et al. Pharmacology of P2X channels. Pflugers Arch 452:513-37 (2006). Read more (PubMed: 16649055) »
    • Zhuang S & Schnellmann RG Suramin promotes proliferation and scattering of renal epithelial cells. J Pharmacol Exp Ther 314:383-90 (2005). Read more (PubMed: 15833899) »
    • Suzuki E  et al. Divergent effects of the purinoceptor antagonists suramin and pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Mol Pharmacol 66:1738-47 (2004). Read more (PubMed: 15448189) »

    See 1 Publication for this product

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