-
Function
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
-
Tissue specificity
Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
-
Sequence similarities
Belongs to the IAP family.
Contains 1 BIR repeat.
-
Developmental stage
Expression is cell cycle-dependent and peaks at mitosis.
-
Domain
The BIR repeat is necessary and sufficient for HBXIP binding.
-
Post-translational
modifications
Ubiquitination is required for centrosomal targeting.
In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes.
-
Cellular localization
Cytoplasm. Nucleus. Chromosome. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
-
Information by UniProt
-
Database links
-
Alternative names
- API4 antibody
- Apoptosis inhibitor 4 antibody
- Apoptosis inhibitor survivin antibody
- Apoptosis inhibitor4 antibody
- Baculoviral IAP repeat containing 5 antibody
- Baculoviral IAP repeat containing protein 5 antibody
- Baculoviral IAP repeat-containing protein 5 antibody
- BIRC 5 antibody
- BIRC5 antibody
- BIRC5_HUMAN antibody
- EPR 1 antibody
- IAP4 antibody
- Survivin variant 3 alpha antibody
- SVV antibody
- TIAP antibody
see all