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ab12073 has been referenced in 36 publications.

  • Knutson SK  et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther 13:842-54 (2014). ChIP . PubMed: 24563539
  • Negishi M  et al. A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins. PLoS One 9:e95216 (2014). IP . PubMed: 24748121
  • Shi L  et al. Noncoding RNAs and LRRFIP1 regulate TNF expression. J Immunol 192:3057-67 (2014). PubMed: 24567534
  • Bahar Halpern K  et al. Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development. J Biol Chem 289:23882-92 (2014). ChIP . PubMed: 25016019
  • Benard A  et al. Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer. PLoS One 9:e108265 (2014). WB, IHC-P ; Human . PubMed: 25243792
  • Manning CS  et al. Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells. Oncogene 0:N/A (2014). PubMed: 25381824
  • Xi S  et al. Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J Clin Invest 123:1241-61 (2013). ChIP ; Human . PubMed: 23426183
  • Corvetta D  et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem 288:8332-41 (2013). ChIP ; Human . PubMed: 23362253
  • Bengani H  et al. Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. PLoS One 8:e67217 (2013). PubMed: 23805300
  • Saha S  et al. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol 14:37 (2013). PubMed: 23879974
  • Holdt LM  et al. Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet 9:e1003588 (2013). PubMed: 23861667
  • Woo CJ  et al. Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters. Mol Cell Biol 33:3274-85 (2013). PubMed: 23775117
  • Hosogane M  et al. Ras-induced changes in H3K27me3 occur after those in transcriptional activity. PLoS Genet 9:e1003698 (2013). WB . PubMed: 24009517
  • Li J  et al. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci 16:1745-53 (2013). PubMed: 24162653
  • Toth Z  et al. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog 9:e1003813 (2013). Human . PubMed: 24367262
  • Wang C  et al. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res 72:315-24 (2012). WB, ChIP . PubMed: 22068036
  • Kim YW & Kim A Characterization of histone H3K27 modifications in the ß-globin locus. Biochem Biophys Res Commun 405:210-5 (2011). ChIP ; Human . PubMed: 21219849
  • Zeng Y  et al. p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res 71:2781-92 (2011). PubMed: 21447739
  • Vernimmen D  et al. Polycomb eviction as a new distant enhancer function. Genes Dev 25:1583-8 (2011). ChIP ; Mouse . PubMed: 21828268
  • Maenner S  et al. 2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol 8:e1000276 (2010). WB . PubMed: 20052282
  • Lu TY  et al. Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem 285:8719-32 (2010). ChIP ; Human . PubMed: 20064925
  • Seenundun S  et al. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J 29:1401-11 (2010). ChIP ; Mouse . PubMed: 20300060
  • Gupta RA  et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464:1071-6 (2010). WB, ChIP/Chip ; Human . PubMed: 20393566
  • Wang L  et al. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A 107:7317-22 (2010). WB, ChIP ; Mouse . PubMed: 20368440
  • Fu CT  et al. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation. Blood 115:4715-24 (2010). WB ; Human . PubMed: 20371743
  • Iliopoulos D  et al. Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells. Mol Cell 39:761-72 (2010). WB, ChIP ; Human . PubMed: 20832727
  • Khalil AM  et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A 106:11667-72 (2009). ChIP, WB, RIP ; Human . PubMed: 19571010
  • Khalil AM  et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A 106:11667-72 (2009). WB, ChIP, RIP ; Human . PubMed: 19571010
  • Sing A  et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell 138:885-97 (2009). ChIP ; Mouse . PubMed: 19737517
  • Wen H  et al. Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 111:1797-804 (2008). PubMed: 18055863
  • Yamashita M  et al. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med 205:1109-20 (2008). PubMed: 18411339
  • Kia SK  et al. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol 28:3457-64 (2008). WB, ChIP ; Human . PubMed: 18332116
  • Gal-Yam EN  et al. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A 105:12979-84 (2008). WB ; Human . PubMed: 18753622
  • Herranz N  et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol 28:4772-81 (2008). IP ; Human . PubMed: 18519590
  • Crusselle-Davis VJ  et al. Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor. FEBS J 274:6065-73 (2007). PubMed: 17970752
  • Chen H  et al. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem 280:22437-44 (2005). PubMed: 15817459

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