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ab12073 has been referenced in 85 publications.

  • Wang XQ & Dostie J Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation. Nucleic Acids Res 45:1091-1104 (2017). WB, RIP ; Human . PubMed: 28180285
  • Qu Y  et al. c-Myc is Required for BRAF(V600E)-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis. Theranostics 7:2092-2107 (2017). WB ; Human . PubMed: 28656062
  • Casa V  et al. Polycomb repressive complex 1 provides a molecular explanation for repeat copy number dependency in FSHD muscular dystrophy. Hum Mol Genet 26:753-767 (2017). WB, ChIP . PubMed: 28040729
  • Hu H  et al. Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma. Cancer Cell Int 17:26 (2017). PubMed: 28228691
  • Zhang K  et al. The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFß and Notch pathways. Nat Commun 8:144 (2017). PubMed: 28747678
  • Liu H  et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget 7:56338-56354 (2016). IHC . PubMed: 27472460
  • Mahara S  et al. HIFI-a activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc Natl Acad Sci U S A 113:E3735-44 (2016). PubMed: 27303043
  • Chung HR  et al. PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife 5:N/A (2016). IP . PubMed: 27223324
  • Wang XQ & Dostie J Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation. Nucleic Acids Res N/A:N/A (2016). WB ; Human . PubMed: 27789700
  • Lee NK  et al. Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. Oncotarget 7:75307-75318 (2016). WB ; Human . PubMed: 27659532
  • Labade AS  et al. HOXA repression is mediated by nucleoporin Nup93 assisted by its interactors Nup188 and Nup205. Epigenetics Chromatin 9:54 (2016). WB ; Human . PubMed: 27980680
  • Fagnocchi L  et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun 7:11903 (2016). Mouse . PubMed: 27301576
  • Schmitt AM  et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet 48:1370-1376 (2016). PubMed: 27668660
  • Liu GY  et al. The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster. Nucleic Acids Res 44:2613-27 (2016). ChIP ; Mouse . PubMed: 26615201
  • Liao MY  et al. Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer. Int J Oncol 46:1788-800 (2015). PubMed: 25652097
  • Lei I  et al. BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation. J Biol Chem 290:19343-52 (2015). PubMed: 26070559
  • Valletta S  et al. ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts. Oncotarget 6:44061-71 (2015). PubMed: 26623729
  • Englert NA  et al. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem 290:2264-78 (2015). PubMed: 25391650
  • Abou El Hassan M  et al. Polycomb Repressive Complex 2 Confers BRG1 Dependency on the CIITA Locus. J Immunol 194:5007-13 (2015). WB, ChIP ; Human . PubMed: 25862816
  • Jacinto FV  et al. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev 29:1224-38 (2015). PubMed: 26080816
  • LaFave LM  et al. Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med 21:1344-9 (2015). WB . PubMed: 26437366
  • Wurm S  et al. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev 29:144-56 (2015). WB, ChIP ; Mouse . PubMed: 25547114
  • Hatanaka Y  et al. Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons. Proc Natl Acad Sci U S A 112:14641-6 (2015). ICC/IF ; Mouse . PubMed: 26546670
  • Abraham S  et al. The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. J Biol Chem 290:7185-94 (2015). PubMed: 25631048
  • Vlachogiannis G  et al. The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis. Cell Rep N/A:N/A (2015). PubMed: 25683717
  • Bogu GK  et al. Chromatin and RNA Maps Reveal Regulatory Long Noncoding RNAs in Mouse. Mol Cell Biol 36:809-19 (2015). PubMed: 26711262
  • Bhatnagar S  et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature 516:116-20 (2014). PubMed: 25470042
  • Benard A  et al. Prognostic Value of Polycomb Proteins EZH2, BMI1 and SUZ12 and Histone Modification H3K27me3 in Colorectal Cancer. PLoS One 9:e108265 (2014). WB, IHC-P ; Human . PubMed: 25243792
  • Manning CS  et al. Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells. Oncogene 0:N/A (2014). PubMed: 25381824
  • Knutson SK  et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther 13:842-54 (2014). ChIP . PubMed: 24563539
  • Negishi M  et al. A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins. PLoS One 9:e95216 (2014). IP . PubMed: 24748121
  • Shi L  et al. Noncoding RNAs and LRRFIP1 regulate TNF expression. J Immunol 192:3057-67 (2014). PubMed: 24567534
  • Bahar Halpern K  et al. Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development. J Biol Chem 289:23882-92 (2014). ChIP . PubMed: 25016019
  • Xi S  et al. Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J Clin Invest 123:1241-61 (2013). ChIP ; Human . PubMed: 23426183
  • Corvetta D  et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem 288:8332-41 (2013). ChIP ; Human . PubMed: 23362253
  • Bengani H  et al. Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. PLoS One 8:e67217 (2013). PubMed: 23805300
  • Saha S  et al. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. BMC Pharmacol Toxicol 14:37 (2013). PubMed: 23879974
  • Holdt LM  et al. Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet 9:e1003588 (2013). PubMed: 23861667
  • Woo CJ  et al. Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters. Mol Cell Biol 33:3274-85 (2013). PubMed: 23775117
  • Hosogane M  et al. Ras-induced changes in H3K27me3 occur after those in transcriptional activity. PLoS Genet 9:e1003698 (2013). WB . PubMed: 24009517
  • Li J  et al. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci 16:1745-53 (2013). PubMed: 24162653
  • Toth Z  et al. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog 9:e1003813 (2013). Human . PubMed: 24367262
  • Pan X  et al. YY1 controls Ig? repertoire and B-cell development, and localizes with condensin on the Ig? locus. EMBO J 32:1168-82 (2013). PubMed: 23531880
  • Vanharanta S  et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med 19:50-6 (2013). WB . PubMed: 23223005
  • Moison C  et al. DNA methylation associated with polycomb repression in retinoic acid receptor ß silencing. FASEB J 27:1468-78 (2013). PubMed: 23299856
  • Zhang Y  et al. MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol Chem 288:23659-65 (2013). WB . PubMed: 23821546
  • Banaszynski LA  et al. Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells. Cell 155:107-20 (2013). PubMed: 24074864
  • Martin N  et al. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation. EMBO J 32:982-95 (2013). PubMed: 23455154
  • Su L  et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 21:333-47 (2012). PubMed: 22439931
  • Abdel-Wahab O  et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 22:180-93 (2012). PubMed: 22897849
  • Zhao JC  et al. Cooperation between Polycomb and androgen receptor during oncogenic transformation. Genome Res 22:322-31 (2012). ChIP . PubMed: 22179855
  • Patel SR  et al. Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression. Mol Cell 45:185-95 (2012). PubMed: 22169276
  • Ng SY  et al. Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J 31:522-33 (2012). PubMed: 22193719
  • Wang C  et al. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res 72:315-24 (2012). WB, ChIP . PubMed: 22068036
  • Kim YW & Kim A Characterization of histone H3K27 modifications in the ß-globin locus. Biochem Biophys Res Commun 405:210-5 (2011). ChIP ; Human . PubMed: 21219849
  • Zeng Y  et al. p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res 71:2781-92 (2011). PubMed: 21447739
  • Vernimmen D  et al. Polycomb eviction as a new distant enhancer function. Genes Dev 25:1583-8 (2011). ChIP ; Mouse . PubMed: 21828268
  • Mejetta S  et al. Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO J 30:3635-46 (2011). PubMed: 21811233
  • Vitobello A  et al. Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation. Dev Cell 20:469-82 (2011). PubMed: 21497760
  • Prensner JR  et al. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol 29:742-9 (2011). ChIP . PubMed: 21804560
  • Chakravarthy H  et al. Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery. FASEB J 25:206-18 (2011). ChIP . PubMed: 20876214
  • Luis NM  et al. Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4. Cell Stem Cell 9:233-46 (2011). IF . PubMed: 21885019
  • Kwon MJ  et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis 31:974-83 (2010). WB . PubMed: 20053926
  • Gehani SS  et al. Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell 39:886-900 (2010). ChIP ; Human . PubMed: 20864036
  • Toth Z  et al. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 6:e1001013 (2010). PubMed: 20661424
  • Maenner S  et al. 2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol 8:e1000276 (2010). WB . PubMed: 20052282
  • Lu TY  et al. Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem 285:8719-32 (2010). ChIP ; Human . PubMed: 20064925
  • Seenundun S  et al. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J 29:1401-11 (2010). ChIP ; Mouse . PubMed: 20300060
  • Gupta RA  et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464:1071-6 (2010). WB, ChIP/Chip ; Human . PubMed: 20393566
  • Wang L  et al. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A 107:7317-22 (2010). WB, ChIP ; Mouse . PubMed: 20368440
  • Fu CT  et al. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation. Blood 115:4715-24 (2010). WB ; Human . PubMed: 20371743
  • Iliopoulos D  et al. Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells. Mol Cell 39:761-72 (2010). WB, ChIP ; Human . PubMed: 20832727
  • Kheradmand Kia S  et al. EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence. Epigenetics Chromatin 2:16 (2009). WB ; Human . PubMed: 19954516
  • Khalil AM  et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A 106:11667-72 (2009). WB, ChIP, RIP ; Human . PubMed: 19571010
  • Aranda P  et al. Epigenetic signatures associated with different levels of differentiation potential in human stem cells. PLoS One 4:e7809 (2009). ChIP . PubMed: 19915669
  • Suvà ML  et al. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res 69:9211-8 (2009). PubMed: 19934320
  • Sing A  et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell 138:885-97 (2009). ChIP ; Mouse . PubMed: 19737517
  • Ku M  et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 4:e1000242 (2008). ChIP . PubMed: 18974828
  • Wen H  et al. Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 111:1797-804 (2008). PubMed: 18055863
  • Yamashita M  et al. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med 205:1109-20 (2008). PubMed: 18411339
  • Kia SK  et al. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol 28:3457-64 (2008). WB, ChIP ; Human . PubMed: 18332116
  • Gal-Yam EN  et al. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A 105:12979-84 (2008). WB ; Human . PubMed: 18753622
  • Herranz N  et al. Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol 28:4772-81 (2008). IP ; Human . PubMed: 18519590
  • Crusselle-Davis VJ  et al. Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor. FEBS J 274:6065-73 (2007). PubMed: 17970752
  • Chen H  et al. Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. J Biol Chem 280:22437-44 (2005). PubMed: 15817459

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