Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-LKHHSENKGLDKV
    • Amino acids
      113 to 125

Specifications

Our Abpromise guarantee covers the use of ab45744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • FLJ53045
    • FLJ53762
    • FLJ54296
    • HGNC:11486
    • OTTHUMP00000024258
    • OTTHUMP00000024259
    • OTTHUMP00000225953
    • SYBL 1
    • SYBL1
    • Synaptobrevin like 1
    • Synaptobrevin-like protein 1
    • Tetanus insensitive VAMP
    • Tetanus neurotoxin insensitive VAMP
    • Tetanus-insensitive VAMP
    • TI VAMP
    • Ti-VAMP
    • TIVAMP
    • VAMP-7
    • VAMP7
    • VAMP7_HUMAN
    • Vesicle-associated membrane protein 7
    see all
  • Function
    Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
  • Tissue specificity
    Detected in all tissues tested.
  • Sequence similarities
    Belongs to the synaptobrevin family.
    Contains 1 longin domain.
    Contains 1 v-SNARE coiled-coil homology domain.
  • Cellular localization
    Cytoplasmic vesicle > secretory vesicle membrane. Golgi apparatus > trans-Golgi network membrane. Late endosome membrane. Lysosome membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle > phagosome membrane.
  • Information by UniProt

References

ab45744 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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