Anti-Synapsin I (phospho S549) antibody (ab60070)

Overview

  • Product name
    Anti-Synapsin I (phospho S549) antibody
    See all Synapsin I primary antibodies
  • Description
    Rabbit polyclonal to Synapsin I (phospho S549)
  • Specificity
    ab60070 recognises synapsin I, phosphorylated at serine residue 549.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Cow, Dog, Human, Non human primates
  • Immunogen

    Phosphopeptide corresponding to amino acid sequence surrounding the phosphorylated serine 549 of synapsin I.

  • Positive control
    • Rat cortex cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab60070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 74 kDa.

Target

  • Function
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • Involvement in disease
    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • Sequence similarities
    Belongs to the synapsin family.
  • Post-translational
    modifications
    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

References

ab60070 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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