Anti-Synapsin I (phospho S62) antibody (ab59262)

Overview

  • Product nameAnti-Synapsin I (phospho S62) antibody
    See all Synapsin I primary antibodies
  • Description
    Rabbit polyclonal to Synapsin I (phospho S62)
  • SpecificityDetects endogenous levels of Synapsin1 only when phosphorylated at serine 62.
  • Tested applicationsSuitable for: IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic phosphopeptide derived from Human Synapsin 1 around the phosphorylation site of serine 62 (V-A-SP-P-A).

  • Positive control
    • Human brain tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab59262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
ELISA 1/10000.

Target

  • FunctionNeuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • Involvement in diseaseDefects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • Sequence similaritiesBelongs to the synapsin family.
  • Post-translational
    modifications
    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

Anti-Synapsin I (phospho S62) antibody images

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab95262 at a dilution of 1/50-1/100. Left hand image - without immunising peptide; right hand image - with immunising peptide.

References for Anti-Synapsin I (phospho S62) antibody (ab59262)

ab59262 has not yet been referenced specifically in any publications.

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