Anti-Synaptobrevin antibody [SP10] (ab24735)

Overview

  • Product nameAnti-Synaptobrevin antibody [SP10]
    See all Synaptobrevin primary antibodies
  • Description
    Mouse monoclonal [SP10] to Synaptobrevin
  • SpecificityThis antibody reacts with native, denatured and recombinant synaptic vesicle proteins Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2 expressed in a bacterial system (aa 33-96).
  • Tested applicationsSuitable for: WB, ICC, ELISAmore details
  • Species reactivity
    Reacts with: Human, Pig
  • Immunogen

    Tissue/ cell preparation (Human) -a crude synaptic preparation of post mortem human brain.

  • General notes


    The antibody is particularly valuable for immunocytochemical studies of the brain due to its stability in formalin sections.

Properties

Applications

Our Abpromise guarantee covers the use of ab24735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 13 kDa.
ICC 1/1000.
ELISA 1/5000.

Target

  • RelevanceSynaptobrevins are highly conserved between vertebrates and invertebrates. It is a major constituent of synaptic vesicles and peptidergic secretory granules in all neurons examined so far. In addition, it is present on secretory granules of neuroendocrine cells. Synaptobrevins, Syntaxins, and the 25 kDa synaptosomal associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
  • Cellular localizationCytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane. Single-pass type IV membrane protein. Cell junction > synapse > synaptosome. Isoform 3 is found in mitochondria, mitochondrial outer membrane.
  • Database links
  • Alternative names
    • SYB antibody
    • SYB1 antibody
    • Synaptobrevin 1 antibody
    • VAMP antibody
    • VAMP1 antibody
    • Vesicle associated membrane protein 1 antibody
    see all

References for Anti-Synaptobrevin antibody [SP10] (ab24735)

ab24735 has not yet been referenced specifically in any publications.

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