ICC/IF, WBmore details Unsuitable for:
Flow Cyt,IHC-P or IP
Mouse, Rat, Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Synaptophysin aa 250 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: P08247
Rat brain, PC12, Mouse brain and Human brain lysates; PC12 cells.
This product is a recombinant rabbit monoclonal antibody.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100.
1/1000 - 1/5000. Detects a band of approximately 38 kDa (predicted molecular weight: 33 kDa).
Is unsuitable for Flow Cyt,IHC-P or IP.
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
Involvement in disease
Mental retardation, X-linked, SYP-related
Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.
The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.