Overview

  • Product nameAnti-Synaptophysin antibody [SP11]
    See all Synaptophysin primary antibodies
  • Description
    Rabbit monoclonal [SP11] to Synaptophysin
  • Tested applicationsSuitable for: WB, IHC-P, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human).

  • EpitopeC-terminus
  • Positive control
    • Pancreas or Pheochromocytoma

Properties

Applications

Our Abpromise guarantee covers the use of ab16659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200. Predicted molecular weight: 38 kDa.
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-FoFr Use at an assay dependent concentration.

Target

  • FunctionPossibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • Tissue specificityCharacteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
  • Involvement in diseaseMental retardation, X-linked, SYP-related
  • Sequence similaritiesBelongs to the synaptophysin/synaptobrevin family.
    Contains 1 MARVEL domain.
  • DomainThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Cellular localizationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Major synaptic vesicle protein p38 antibody
    • MRX96 antibody
    • MRXSYP antibody
    • Syn p38 antibody
    • Synaptophysin antibody
    • Syp antibody
    • SYPH antibody
    • SYPH_HUMAN antibody
    • SypI antibody
    see all

Anti-Synaptophysin antibody [SP11] images

  • Immunohistochemical staining of human neuroendocrine tumor with ab16659.

  • Immunohistochemical staining of human pancreas with ab16659.

  • Anti-Synaptophysin antibody [SP11] (ab16659) + lysate prepared from brain

    Predicted band size : 38 kDa

References for Anti-Synaptophysin antibody [SP11] (ab16659)

This product has been referenced in:

See 1 Publication for this product

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Thank you for your enquiry. We don't have a blocking peptide for this antibody within our product range. Best of luck with your research.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"