Overview

  • Product name
    Anti-Synaptopodin 2 antibody
    See all Synaptopodin 2 primary antibodies
  • Description
    Rabbit polyclonal to Synaptopodin 2
  • Tested applications
    Suitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide:

    QQNGFSGTSETANIQRMVPM

    conjugated to KLH, corresponding to amino acids 566-585 in the mid region of Human Synaptopodin 2. This sequence is not found in human or rat synaptopodin.

  • Positive control
    • WB: A cytosolic fraction of rat skeletal muscle. IHC-Fr: rat skeletal muscle and rat kidney.

Properties

Applications

Our Abpromise guarantee covers the use of ab50192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 118 kDa. Additional lower bands may be observed which may represent degradation products. The staining can be blocked by the immunizing peptide.
IHC-Fr Use a concentration of 1 - 2 µg/ml.

Target

  • Function
    Has an actin-binding and actin-bundling activity.
  • Tissue specificity
    Skeletal muscle-specific.
  • Sequence similarities
    Belongs to the synaptopodin family.
    Contains 1 PDZ (DHR) domain.
  • Cellular localization
    Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686G051 antibody
    • Genethonin 2 antibody
    • Genethonin-2 antibody
    • Myopodin antibody
    • striated muscle specific antibody
    • Synaptopodin-2 antibody
    • SYNP2_HUMAN antibody
    • SYNPO 2 antibody
    • Synpo2 antibody
    see all

References

This product has been referenced in:
  • Kai F  et al. Myopodin isoforms alter the chemokinetic response of PC3 cells in response to different migration stimuli via differential effects on Rho-ROCK signaling pathways. Carcinogenesis 33:2100-7 (2012). Read more (PubMed: 22915763) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab50192.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up