Anti-Synaptopodin antibody (ab117702)
Key features and details
- Rabbit polyclonal to Synaptopodin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Synaptopodin antibody
See all Synaptopodin primary antibodies -
Description
Rabbit polyclonal to Synaptopodin -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide from the C terminal region of Human Synaptopodin, conjugated to KLH.
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Positive control
- Human perineural or perivascular process.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117702 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. -
Tissue specificity
Expressed in cerebral cortex. -
Sequence similarities
Belongs to the synaptopodin family. -
Post-translational
modificationsO-glycosylated.
Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-871. -
Cellular localization
Cytoplasm > cytoskeleton. Cell junction > tight junction. Perikaryon. Cell projection > dendritic spine. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Asssociated with dendritic spines of a subset of synapses. - Information by UniProt
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Database links
- Entrez Gene: 11346 Human
- Entrez Gene: 104027 Mouse
- Entrez Gene: 60324 Rat
- Omim: 608155 Human
- SwissProt: Q8N3V7 Human
- SwissProt: Q8CC35 Mouse
- SwissProt: Q9Z327 Rat
- Unigene: 435228 Human
see all -
Alternative names
- KIAA1029 antibody
- Synaptopodin antibody
- SYNPO antibody
- SYNPO_HUMAN antibody
Images
Datasheets and documents
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Datasheet download
References (4)
ab117702 has been referenced in 4 publications.
- Kosovic I et al. Spatio-temporal patterning of different connexins in developing and postnatal human kidneys and in nephrotic syndrome of the Finnish type (CNF). Sci Rep 10:8756 (2020). PubMed: 32471989
- Che X et al. Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/ß-catenin signaling. PeerJ 7:e8016 (2019). PubMed: 31799068
- Subramanian A et al. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun 10:5462 (2019). PubMed: 31784515
- Zhang Q et al. Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1. Cell Physiol Biochem 48:1-15 (2018). PubMed: 29996125