Four synthetic peptides conjugated to KLH, corresponding to different regions of the Synaptotagmin 1 gene product, but are shared between the human (NP_005630, NCBI) and mouse (NP_033332, NCBI) sequences.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Sequence similaritiesBelongs to the synaptotagmin family. Contains 2 C2 domains.
DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with SV2A and STN2.