Overview

  • Product nameAnti-Synaptotagmin 1 antibodySee all Synaptotagmin 1 primary antibodies ...
  • Description
    Rabbit polyclonal to Synaptotagmin 1
  • Specificitythis antibody reacts with Synaptotagmin 1
  • Tested applicationsWB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide as a part of human Synaptotagmin 1 conjugated to an immunogenic carrier protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab68856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/300 - 1/3000. Predicted molecular weight: 48 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
IHC-P 1/300 - 1/3000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr 1/300 - 1/3000.

Target

  • FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
  • Sequence similaritiesBelongs to the synaptotagmin family.
    Contains 2 C2 domains.
  • DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
    The second C2 domain mediates interaction with SV2A and STN2.
  • Cellular localizationCytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781D2042 antibody
    • P65 antibody
    • SVP65 antibody
    • Synaptotagmin I antibody
    • Synaptotagmin-1 antibody
    • SYT antibody
    • SYT1 antibody
    • SYT1_HUMAN antibody
    • SytI antibody
    see all

References for Anti-Synaptotagmin 1 antibody (ab68856)

ab68856 has not yet been referenced specifically in any publications.

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