Overview

  • Product name
    Anti-Synaptotagmin 1 antibody
    See all Synaptotagmin 1 primary antibodies
  • Description
    Rabbit polyclonal to Synaptotagmin 1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Xenopus laevis
    Does not react with: Mouse
  • Immunogen

    Synthetic peptide derived from sequence near the amino terminus of rat Synaptotagmin 1, conjugated to KLH

  • Positive control
    • Rat Brain and Xenopus Ovary lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab82414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 65 kDa (predicted molecular weight: 48 kDa).

Target

  • Function
    May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
  • Sequence similarities
    Belongs to the synaptotagmin family.
    Contains 2 C2 domains.
  • Domain
    The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
    The second C2 domain mediates interaction with SV2A and STN2.
  • Cellular localization
    Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane. Cytoplasm. Synaptic vesicles and chromaffin granules.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781D2042 antibody
    • FLJ42519 antibody
    • p65 antibody
    • SVP65 antibody
    • Synaptotagmin 2 antibody
    • Synaptotagmin I antibody
    • Synaptotagmin II antibody
    • Synaptotagmin-1 antibody
    • SYT antibody
    • Syt1 antibody
    • SYT1_HUMAN antibody
    • Syt2 antibody
    • SytI antibody
    see all

Images

  • All lanes : Anti-Synaptotagmin 1 antibody (ab82414) at 1/1000 dilution

    Lane 1 : Rat Brain lysate
    Lane 2 : Mouse Brain lysate
    Lane 3 : Xenopus Ovary lysate

    Developed using the ECL technique

    Predicted band size : 48 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)

References

ab82414 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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