Anti-Synaptotagmin antibody (ab51172)

Overview

  • Product nameAnti-Synaptotagmin antibodySee all Synaptotagmin primary antibodies ...
  • Description
    Rabbit polyclonal to Synaptotagmin
  • SpecificityThis antibody reacts with endogenous levels of total Synaptotagmin protein.
  • Tested applicationsELISA, IHC-P more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthesized non-phosphopeptide derived from human Synaptotagmin around the phosphorylation site of threonine 202.

  • Positive control
    • Human breast carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab51172 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA 1/10000.
IHC-P Use at an assay dependent dilution.

Target

  • RelevanceThe synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • DKFZp781D2042 antibody
    • P65 antibody
    • SVP65 antibody
    • Synaptotagmin I antibody
    • Synaptotagmin II antibody
    • Synaptotagmin IV antibody
    • Synaptotagmin V antibody
    • SYT 1 antibody
    • SYT antibody
    • SYT1 antibody
    • SYT2 antibody
    • SYT3 antibody
    • SYT4 antibody
    • SYT5 antibody
    • SytI antibody
    see all

Anti-Synaptotagmin antibody images

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab51172 at a 1:50 dilution. Left image un-treated; Right image treated with peptide.

References for Anti-Synaptotagmin antibody (ab51172)

ab51172 has not yet been referenced specifically in any publications.

Product Wall

Thank you for providing the sequence and for your patience.

After aligning the sequences, I am afraid it is not very likely that any of the Anti-Synaptotagmin antibodies available will recognise the Arabidopsis protein, as the homologies are ...

Read More

Thank you for contacting us.

As none of our anti Synaptotagmin antibodies have been tested in Arabidopsis we cannot state whether they will cross react with it or not. In order to check the percentage of homology between the sequences, I woul...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"