Anti-Synaptotagmin antibody (ab51172)
- Product nameAnti-Synaptotagmin antibodySee all Synaptotagmin primary antibodies ...
- DescriptionRabbit polyclonal to Synaptotagmin
- SpecificityThis antibody reacts with endogenous levels of total Synaptotagmin protein.
- Tested applicationsELISA, IHC-P more details
- Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
A synthesized non-phosphopeptide derived from human Synaptotagmin around the phosphorylation site of threonine 202.
- Positive control
- Human breast carcinoma tissue
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Clonality Polyclonal
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
Our Abpromise guarantee covers the use of ab51172 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: Use at an assay dependent dilution.|
- RelevanceThe synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
- Cellular localizationCytoplasmic
- Entrez Gene: 127833 Human
- Entrez Gene: 6857 Human
- Entrez Gene: 6860 Human
- Entrez Gene: 6861 Human
- Entrez Gene: 84258 Human
- Entrez Gene: 20979 Mouse
- Entrez Gene: 25716 Rat
- Omim: 185605 Human
- SwissProt: O00445 Human
- SwissProt: P21579 Human
- SwissProt: Q8N9I0 Human
- SwissProt: Q9BQG1 Human
- SwissProt: Q9H2B2 Human
- SwissProt: P46096 Mouse
- SwissProt: P21707 Rat
- Unigene: 154679 Human
- Unigene: 216272 Rat
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- SVP65 antibody
- Synaptotagmin I antibody
- Synaptotagmin II antibody
- Synaptotagmin IV antibody
- Synaptotagmin V antibody
- SYT 1 antibody
- SYT antibody
- SYT1 antibody
- SYT2 antibody
- SYT3 antibody
- SYT4 antibody
- SYT5 antibody
- SytI antibody
Anti-Synaptotagmin antibody images
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab51172 at a 1:50 dilution. Left image un-treated; Right image treated with peptide.
References for Anti-Synaptotagmin antibody (ab51172)
ab51172 has not yet been referenced specifically in any publications.