Overview

  • Product name
  • Description
    Goat polyclonal to SynGAP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Synthetic peptide:

    DEDEIHPLLIRDR-C

    (with a Cysteine residue linker), corresponding to N terminal amino acids 60-72 of Human SynGAP (NP_006763.2; Q96PV0).

  • Positive control
    • Mouse Brain lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 148 kDa.

Target

  • Function
    Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
  • Involvement in disease
    Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
  • Sequence similarities
    Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
  • Post-translational
    modifications
    Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp761G1421 antibody
    • KIAA1938 antibody
    • MRD5 antibody
    • Neuronal RasGAP antibody
    • OTTHUMP00000064825 antibody
    • p135 SynGAP antibody
    • Ras GTPase activating protein SynGAP antibody
    • Ras GTPase-activating protein SynGAP antibody
    • RASA 1 antibody
    • RASA 5 antibody
    • RASA1 antibody
    • RASA5 antibody
    • SYGP1_HUMAN antibody
    • Synaptic Ras GAP 1 antibody
    • Synaptic Ras GTPase activating protein 1 antibody
    • Synaptic Ras GTPase activating protein 1 homolog antibody
    • Synaptic Ras GTPase activating protein 135kDa antibody
    • Synaptic Ras GTPase activating protein antibody
    • Synaptic Ras GTPase-activating protein 1 antibody
    • Synaptic Ras-GAP 1 antibody
    • SYNGAP 1 antibody
    • SYNGAP1 antibody
    see all

Images

  • Anti-SynGAP antibody (ab126871) at 2 µg/ml + Mouse Brain lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 148 kDa


    Exposure time : 1 hour

References

ab126871 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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