Anti-Syntaxin 16 antibody - C-terminal (ab170560)

Overview

  • Product name
    Anti-Syntaxin 16 antibody - C-terminal
    See all Syntaxin 16 primary antibodies
  • Description
    Rabbit polyclonal to Syntaxin 16 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Syntaxin 16 aa 254-282 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: O14662

  • Positive control
    • 293 cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

Target

  • Function
    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) [MIM:603233]. Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B.
  • Sequence similarities
    Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localization
    Cytoplasm and Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • hsyn16 antibody
    • MGC90328 antibody
    • Stx16 antibody
    • STX16_HUMAN antibody
    • Syn16 antibody
    • Syntaxin-16 antibody
    see all

Images

  • Anti-Syntaxin 16 antibody - C-terminal (ab170560) at 1/100 dilution + 293 cell line lysates at 35 µg

    Predicted band size: 37 kDa

  • Flow cytometric analysis of 293 cells labelling Syntaxin 16  with ab170560 at 1/10 dilution (right histogram) compared to a negative control cells (left histogram). FITC-conjugated goat-anti-rabbit secondary was used for analysis.

References

ab170560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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