ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Involvement in disease
Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) [MIM:603233]. Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B.
Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain.
Flow cytometric analysis of 293 cells labelling Syntaxin 16 with ab170560 at 1/10 dilution (right histogram) compared to a negative control cells (left histogram). FITC-conjugated goat-anti-rabbit secondary was used for analysis.