Overview

  • Product nameAnti-Syntaxin 1a antibody
    See all Syntaxin 1a primary antibodies
  • Description
    Rabbit polyclonal to Syntaxin 1a
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-251 of Human Syntaxin 1a (AAH03011.1).

  • Positive control
    • Mouse liver lysate; Rat brain lysate; Syntaxin 1a transfected 293T cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab118359 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 29 kDa.
IP Use at an assay dependent dilution.

Target

  • FunctionPotentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
  • Tissue specificityIsoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
  • Involvement in diseaseNote=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similaritiesBelongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localizationSecreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • HPC 1 antibody
    • Neuron specific antigen HPC1 antibody
    • Neuron-specific antigen HPC-1 antibody
    • OTTHUMP00000174615 antibody
    • OTTHUMP00000174616 antibody
    • OTTHUMP00000174617 antibody
    • OTTHUMP00000174618 antibody
    • P35-1 antibody
    • STX1 antibody
    • STX1A antibody
    • STX1A_HUMAN antibody
    • SYN1A antibody
    • Syntaxin 1A (brain) antibody
    • Syntaxin 1A brain antibody
    • Syntaxin-1A antibody
    see all

Anti-Syntaxin 1a antibody images

  • Anti-Syntaxin 1a antibody (ab118359) at 1/1000 dilution + Mouse liver lysate at 50 µg

    Predicted band size : 29 kDa
  • Anti-Syntaxin 1a antibody (ab118359) at 1/1000 dilution + Rat brain lysate at 50 µg

    Predicted band size : 29 kDa
  • All lanes : Anti-Syntaxin 1a antibody (ab118359) at 1/1000 dilution

    Lane 1 : Syntaxin 1a transfected 293T cell line lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 29 kDa
  • Immunoprecipitation of Syntaxin 1a transfected lysate using ab118359 and Protein A Magnetic Bead, immunoblotted with an Anti-Mouse polyclonal antibody.

References for Anti-Syntaxin 1a antibody (ab118359)

ab118359 has not yet been referenced specifically in any publications.

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