Anti-Syntaxin 1a antibody (ab13262)


  • Product name
  • Description
    Rabbit polyclonal to Syntaxin 1a
  • Specificity
    Unfortunately we can not exlude crossreactivity with the very homologue protein Syntaxin 1b as the alignement score of the immunogen is relatively high with mouse Syntaxin 1b.
  • Tested applications
    Suitable for: WB, IHC-P, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Chicken, Human, Zebrafish
  • Immunogen

    Synthetic peptide:


    conjugated to KLH, corresponding to amino acids 1-19 of Human Syntaxin.

  • Positive control
    • Rat or Mouse Brain Tissue Extract.



Our Abpromise guarantee covers the use of ab13262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 35-36 kDa (predicted molecular weight: 34.6 kDa).
IHC-P Use at an assay dependent concentration.
IP Use at an assay dependent concentration.


  • Function
    Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
  • Tissue specificity
    Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
  • Involvement in disease
    Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
  • Sequence similarities
    Belongs to the syntaxin family.
    Contains 1 t-SNARE coiled-coil homology domain.
  • Cellular localization
    Secreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • HPC 1 antibody
    • Neuron specific antigen HPC1 antibody
    • Neuron-specific antigen HPC-1 antibody
    • OTTHUMP00000174615 antibody
    • OTTHUMP00000174616 antibody
    • OTTHUMP00000174617 antibody
    • OTTHUMP00000174618 antibody
    • P35-1 antibody
    • STX1 antibody
    • STX1A antibody
    • STX1A_HUMAN antibody
    • SYN1A antibody
    • Syntaxin 1A (brain) antibody
    • Syntaxin 1A brain antibody
    • Syntaxin-1A antibody
    see all

Anti-Syntaxin 1a antibody images

  • All lanes : Anti-Syntaxin 1a antibody (ab13262) at 1/2000 dilution

    Lane 1 : Chicken brain tissue lysate
    Lane 2 : Chicken DRG tissue lysate

    Lysates/proteins at 40 µg per lane.

    HRP-conjugated donkey anti-rabbit IgG at 1/10000 dilution

    Performed under non-reducing conditions.

    Predicted band size : 34.6 kDa
    Observed band size : 34 kDa (why is the actual band size different from the predicted?)

    Exposure time : 150 seconds

    This image is courtesy of an anonymous Abreview

    See Abreview

References for Anti-Syntaxin 1a antibody (ab13262)

ab13262 has not yet been referenced specifically in any publications.

Product Wall

Western blot
Loading amount
40 µg
Gel Running Conditions
Non-reduced Denaturing (Extra PAGE ONE 5-20%)
Chicken Tissue lysate - whole (Brain and DRG)
Brain and DRG
Blocking step
Blocking one as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 100% · Temperature: 24°C

Abcam user community

Verified customer

Submitted Feb 13 2015

Thank you very much for your patience while I was in contact with the laboratory. Please find here the alignment or comments to our other Syntaxin-1a antibodies. It was in the end more difficult than expected to find an antibody which I could recommend...

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