Anti-Syntaxin 1a antibody [SP36], prediluted (ab73915)

Overview

  • Product nameAnti-Syntaxin 1a antibody [SP36], prediluted
    See all Syntaxin 1a primary antibodies
  • Description
    Rabbit monoclonal [SP36] to Syntaxin 1a, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to the N terminus of human Syntaxin 1a

  • EpitopeN terminus
  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab73915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready to use for 30 minutes at room temperature.
    Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPotentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
    • Tissue specificityIsoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
    • Involvement in diseaseNote=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
    • Sequence similaritiesBelongs to the syntaxin family.
      Contains 1 t-SNARE coiled-coil homology domain.
    • Cellular localizationSecreted and Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • HPC 1 antibody
      • Neuron specific antigen HPC1 antibody
      • Neuron-specific antigen HPC-1 antibody
      • OTTHUMP00000174615 antibody
      • OTTHUMP00000174616 antibody
      • OTTHUMP00000174617 antibody
      • OTTHUMP00000174618 antibody
      • P35-1 antibody
      • STX1 antibody
      • STX1A antibody
      • STX1A_HUMAN antibody
      • SYN1A antibody
      • Syntaxin 1A (brain) antibody
      • Syntaxin 1A brain antibody
      • Syntaxin-1A antibody
      see all

    Anti-Syntaxin 1a antibody [SP36], prediluted images

    • ab73915, ready to use, staining Syntaxin 1a in formalin fixed, paraffin embedded human brain tissue by Immunohistochemistry.

    References for Anti-Syntaxin 1a antibody [SP36], prediluted (ab73915)

    ab73915 has not yet been referenced specifically in any publications.

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Human Tissue sections (brain, pediatric)
    Specification brain, pediatric
    Fixative Formaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: citrate pH6, 100C 20 minutes
    Permeabilization No
    Username

    Abcam user community

    Verified customer

    Submitted Dec 15 2009

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"