FunctionAdapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-biphosphate.
Tissue specificityHigh expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
Involvement in diseaseDefects in SNTA1 are the cause of long QT syndrome type 12 (LQT12) [MIM:612955]. A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Sequence similaritiesBelongs to the syntrophin family. Contains 1 PDZ (DHR) domain. Contains 2 PH domains. Contains 1 SU (syntrophin unique) domain.
DomainThe PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-biphosphate. The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane. The SU domain binds calmodulin in a calcium-dependent manner.
Post-translational modificationsPhosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD.
Cellular localizationCell membrane > sarcolemma. Cell junction. Cytoplasm > cytoskeleton. In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
59 kDa dystrophin-associated protein A1 acidic component 1 antibody
Acidic alpha 1 syntrophin antibody
Alpha 1 syntrophin antibody
Dystrophin associated protein A1 59kDa acidic component antibody
Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody
Syntrophin 1 antibody
Anti-Syntrophin alpha 1 antibody images
Western blot - Anti-Syntrophin alpha 1 antibody (ab5941)
Predicted band size : 58 kDa
ab5941 at 0.1µg/ml staining Syntrophin alpha 1 at approximately 60kDa in Human Heart Lysate by Western blot (ECL).
References for Anti-Syntrophin alpha 1 antibody (ab5941)
This product has been referenced in:
Harisseh R et al. Involvement of TRPV2 and SOCE in calcium influx disorder in DMD primary human myotubes with a specific contribution of a1-syntrophin and PLC/PKC in SOCE regulation. Am J Physiol Cell Physiol304:C881-94 (2013).
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